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大鼠ip利血平2mg/kg后1-24h,NE,DA,5-HT均显著下降(p<0.05-p<0.001),5-HIAA则显著升高(p<0.001)。ip帕吉林60mg/kg后1-24h,NE,DA,5-HT均显著升高(p<0.01-p<0.001),5-HIAA则在1-2h内显著下降(p<0.01),4-24h无明显变化。同时使用两药时,对鼠脑NE和DA的影响均呈拮抗作用,对5-HT仅表现帕吉林的作用。帕吉林对利血平化鼠的NE,DA无影响,但可使5-HT升至正常水平;利血平对帕吉林化鼠递质的变化无影响。两药合用对递质的影响表现为拮抗或单一作用,未见递质翻转现象。
The levels of NE, DA and 5-HT were significantly decreased (P <0.05-p <0.001) and 5-HIAA was significantly increased (P <0.001) at 1-24 hours after ip reserpine 2mg / kg. The levels of NE, DA and 5-HT were significantly increased (P <0.01-p <0.001) and 5-HIAA significantly decreased within 1-2 hours -24h no significant change. At the same time using the two drugs, the impact of rat brain NE and DA showed antagonistic effect on 5-HT only shows the role of pargyline. Perindoline had no effect on NE and DA in reserpine-induced rats, but raised 5-HT to normal level. Reserpine had no effect on the changes of neurotransmitter in perindulinic rats. The combination of the two drugs on the transmitter for the performance of antagonistic or single role, no transmitter turnover phenomenon.