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1例80岁男性患者,因脑梗死及高脂血症口服阿托伐他汀钙20 mg,1次/d。服药20 d后出现胸痛、胸闷、无力,实验室检查示肌酸激酶(CK)由130 U/L升至741 U/L,同时出现肾功能异常和电解质紊乱。第28天,患者因肺部感染给予莫西沙星注射液0.4 g静脉滴注,之后患者CK由741 U/L升至3565 U/L,停用阿托伐他汀钙;莫西沙星改为头孢哌酮舒巴坦钠。10 d后CK逐渐下降至54 U/L,其他血生化检查均恢复正常。
One 80-year-old man with oral atorvastatin calcium 20 mg once daily for cerebral infarction and hyperlipidemia. Chest pain, chest tightness, and weakness were noted after 20 days of treatment. Laboratory tests showed that creatine kinase (CK) increased from 130 to 741 U / L, with renal dysfunction and electrolyte imbalance. On the 28th day, the patient was given 0.4 g moxifloxacin for pulmonary infection, then CK increased from 741 U / L to 3565 U / L, and atorvastatin calcium was stopped. Moxifloxacin was changed to cefotaxime Sulpirone sulbactam sodium. After 10 days CK gradually decreased to 54 U / L, other blood biochemical tests returned to normal.