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细胞凋亡（ａｐｏｐｔｏｓｉｓ）同胚泡植入及胎盘发育密切相关，为了进一步探讨米非司酮终止早孕的机制，本文随机选择要求人工流产的妇女２５名，服药组１３名，对照组１２名。应用流式细胞仪对经碘化丙锭（ＰＩ）染色后的蜕膜组织细胞ＤＮＡ进行分析。结果两组细胞ＤＮＡ直方图上均出现细胞凋亡峰，其细胞所占比例（ｘ±ｓ）％服药组为６．８２±３．０９，对照组为３．４３±２．１３，服药组明显高于对照组（Ｐ＜０．０１）。二倍体峰细胞比例服药组为７６．００±７．０９，对照组为８４．４５±３．８４，服药组低于对照组（Ｐ＜０．０５）。四倍体峰细胞比例两组分别为３．７０±１．６４、３．２９±０．６７，无明显差别（Ｐ＞０．０５）。结果表明人早孕蜕膜组织中存在着细胞凋亡，米非司酮终止早孕的作用可能是通过拮抗孕激素作用促进蜕膜细胞凋亡而实现的。
In order to further explore the mechanism of mifepristone termination of early pregnancy, 25 randomly selected women with induced abortion, 13 in the medication group and 12 in the control group. Flow cytometry was used to analyze the decidual cell DNA stained with propidium iodide (PI). Results Apoptotic peak appeared on DNA histogram in both groups, with the proportion of cells (x ± s)% in the medication group 6.82 ± 3.09 and that in the control group 3.43 ± 2.13, Obviously higher than the control group (P <0.01). The proportion of diploid peak cells was 76.00 ± 7.09 in the control group and 84.45 ± 3.84 in the control group, which was lower than that in the control group (P <0.05). The tetraploid peak cell ratio in the two groups was 3.70 ± 1.64,3.29 ± 0.67, no significant difference (P> 0.05). The results showed that there is apoptosis in human decidual tissue in early pregnancy, and the effect of mifepristone on termination of early pregnancy may be mediated by progesterone to promote the apoptosis of decidual cells.