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目的评价标准化尘螨变应原治疗儿童支气管哮喘(哮喘)及变应性鼻炎的近期及远期疗效。方法回顾性收集2006年2月-2007年8月在本院应用标准化屋尘螨制剂(安脱达)治疗2.5~3.0 a、且资料完整的患儿共55例,治疗结束后定期随访,分别在3个月、6个月、1.0 a、1.5 a时随访,比较治疗前、治疗结束时、随访时儿童哮喘控制测试(C-ACT)得分、鼻部症状评分、哮喘症状评分、药物评分、呼气峰流速(PEF)值、PEF%,并在治疗结束时由患儿自我评价鼻炎及哮喘疗效。结果 55例完成3个月及6个月随访,39例完成1.0 a随访,25例完成1.5 a随访。55例患儿脱敏治疗前和脱敏治疗结束时C-ACT、鼻部症状评分、哮喘症状评分、用药评分、PEF、PEF%比较,差异均有统计学意义(Pa<0.05);55例患儿脱敏治疗结束时和随访3个月、6个月、1.0 a、1.5 a时C-ACT、鼻部症状评分、哮喘症状评分、药物评分比较,差异均无统计学意义(Pa>0.05)。结论标准化屋尘螨变应原治疗哮喘具有良好的近期疗效和远期疗效。
Objective To evaluate the short-term and long-term effects of standardized house dust mite allergen on bronchial asthma (asthma) and allergic rhinitis in children. Methods Retrospectively collected from February 2006 to August 2007 in our hospital standardized house dust mite preparation (An Dada) for 2.5 ~ 3.0 a, and a total of 55 children with complete data, regular follow-up after the end of treatment, respectively At 3 months, 6 months, 1.0 a and 1.5 a, follow-up was performed. The scores of C-ACT, nasal symptom score, asthma symptom score, drug score, Peak expiratory flow (PEF), PEF%, and self-evaluated rhinitis and asthma outcomes at the end of treatment. Results 55 cases completed 3 months and 6 months follow-up, 39 cases completed 1.0 a follow-up, 25 cases completed 1.5 a follow-up. 55 cases of children with desensitization before and after the end of desensitization treatment C-ACT, nasal symptom scores, asthma symptoms scores, medication scores, PEF, PEF%, the difference was statistically significant (Pa <0.05); 55 cases C-ACT, nasal symptom scores, asthma symptom scores and drug scores were not significantly different at the end of the desensitization treatment and at the follow-up of 3 months, 6 months, 1.0 a and 1.5 years (Pa> 0.05 ). Conclusion Standardized house dust mite allergen treatment of asthma has a good short-term efficacy and long-term efficacy.