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用 DNA 重组技术生产的粒细胞-巨噬细胞集落刺激因子(GM-CSF)和粒细胞集落刺激因子(G-CSF),主要用于治疗继发于化疗、放疗、骨髓移植以及各种中性白细胞减少的骨髓衰竭。在临床常用剂量下其毒性较小。白介素-2(IL-2)主要用于治疗肾细胞癌病人,总有效率为15%～30%,对黑色素瘤的有效率为18%。与其它生物制剂和细胞毒性药物联合应用可增加 IL-2的抗癌疗效。IL-2的毒性主要有低血压、水肿、体重增加和降低肾功能等。
GM-CSF and G-CSF produced by DNA recombination technology are mainly used for the treatment of secondary to chemotherapy, radiotherapy, bone marrow transplantation and a variety of neutral Leukopenia in bone marrow failure. In the clinical dose of its less toxic. Interleukin-2 (IL-2) is mainly used to treat patients with renal cell carcinoma, the total effective rate of 15% to 30%, the efficiency of melanoma was 18%. Combined with other biological agents and cytotoxic drugs can increase the anti-cancer efficacy of IL-2. IL-2 toxicity mainly hypotension, edema, weight gain and reduce renal function.