有研究显示 HLA－ DR、 DQ基因位点与系统性红斑狼疮 (SLE)的发病及某些类型自身抗体的形成密切相关 [1,2]。我们采用聚合酶链反应 (PCR)－序列特异性引物 (SSP)技术进行 HLA－ DRB1、 DQA1、 DQB1基因分型，研究云南汉族 SLE患者抗双链 DNA抗体 (A－ dsDNA)的产生与 HLA－ DRB Studies have shown that HLA-DR, DQ gene loci are closely related to the onset of systemic lupus erythematosus (SLE) and the formation of some types of autoantibodies [1,2]. We performed genotyping of HLA-DRB1, DQA1 and DQB1 by polymerase chain reaction (PCR) -specific primer (SSP) technique to study the relationship between the production of anti-dsDNA antibody and HLA- DRB