论文部分内容阅读
本文对5例肝活检证实的慢性乙型肝炎病人在短程强的松龙撤除后应用重组干扰素α-2b治疗过程中对血清前S_1和前S_2蛋白进行了动态观察。疗程结束时,3例病人的血清前S_1、前S_2蛋白滴度逐渐下降,尤以前S_2蛋白的下降为明显,前S_1和前S_2蛋白的下降与DNAp、HBeAg的消失相关。另2例对此治疗无反应的病人,在治疗期间,血清前S_1和前S_2蛋白无明显变化,在治疗结束时,血清HBV-DNA,DNAp及HBeAg仍阳性。结果提示慢乙肝抗病毒治疗过程中,前S_1和前S_2蛋白的测定有助于监测疗效。
In this paper, 5 cases of patients with chronic hepatitis B confirmed by liver biopsy in the treatment of short-course prednisolone recombinant interferon α-2b during the treatment of pre-serum S_1 and pre-S_2 protein dynamic observation. At the end of the course of treatment, the titer of pre-S 1 and pre-S 2 protein of 3 patients decreased gradually, especially the decline of pre-S 2 protein was obvious. The decrease of pre-S 1 and pre-S 2 protein was related to the disappearance of DNAp and HBeAg. In the other 2 patients who did not respond to this treatment, there was no significant change in serum S 1 and S 2 before treatment. Serum HBV DNA, DNAp and HBeAg were still positive at the end of treatment. The results suggest that during the treatment of chronic hepatitis B virus, the determination of pre-S 1 and pre-S 2 proteins may help to monitor the curative effect.