自然流产的发生率约占妊娠总数的10%~15%,其中早期流产占80%以上[1]。导致自然流产的因素很多,如遗传因素、免疫和环境因素、内分泌失调、生殖器官解剖异常、感染以及创伤等,但仍然有50%以上的自然流产原因不明,称为不明原因性流产。在针对其发病机制的研究中,血管生成因子的作用越来越受到重视,这是因为在妊娠早期,血管发生和血管化是胚胎发育和胎盘形成的基础,而这一过程主要是受血管生成因子 The incidence of spontaneous abortion accounted for about 10% to 15% of the total number of pregnancies, of which more than 80% of early abortion [1]. There are many factors leading to spontaneous abortion, such as genetic factors, immune and environmental factors, endocrine disorders, genital abnormalities, infections and trauma, but still more than 50% of spontaneous abortion for unknown reasons, known as unexplained abortion. In studies of its pathogenesis, the role of angiogenic factors is gaining more and more attention as angiogenesis and vascularization are the foundations of embryonic development and placental formation in early gestation, and this process is mainly mediated by angiogenesis factor