慢性脑膜炎球菌脓毒症

来源 :世界核心医学期刊文摘(皮肤病学分册) | 被引量 : 0次 | 上传用户:csh911229
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Introduction. Chronic meningococcemia is a rare clinical form of invasive Neisseria meningitidis infection. We report 2 cases. Observations. A 39 year- old man and a 42 year- old woman had developed a widespread, fleeting and painful maculopapular cutaneous eruption over the past few weeks, associated with intermittent fever and inflammatory arthralgia. In both cases blood cultures isolated a serogroup B meningococcus that confirmed the diagnosis. Cutaneous histology revealed a nonspecific image of leukocytoclastic vasculitis. Treatment with β .lactamin antibiotics was successful after respectively 3 weeks and 12 days. Discussion. This septicemia is characterized by the clinical triad of cutaneous eruption, fever and arthralgia. It must not be mistaken for connectivitis because inappropriate corticosteroid prescription may provoke severe complications. Confirmation of the diagnosis is provided by the blood cultures, which should be repeated. In the case of strong clinical suspicion, the rapid improvement with antibiotics confirms the diagnosis. Introduction. Chronic meningococcemia is a rare clinical form of invasive Neisseria meningitidis infection. We report 2 cases. Observations. A 39 year- old man and a 42 year- old woman had developed a widespread, fleeting and painful maculopapular cutaneous eruption over the past few weeks, associated with intermittent fever and inflammatory arthralgia. In both cases blood cultures isolated a serogroup B meningococcus that confirmed the diagnosis. Cutaneous histology revealed a nonspecific image of leukocytoclastic vasculitis. Treatment with β. lactamin antibiotics was successful after respectively 3 weeks and 12 days Discussion. This septicemia is characterized by the clinical triad of cutaneous eruption, fever and arthralgia. It must not be mistaken for connectivitis because of inappropriate corticosteroid prescription may provoke severe complications. Confirmation of the diagnosis is provided by the blood cultures, which should be repeated In the case of strong clinical suspicion, t he rapid improvement with antibiotics confirms the diagnosis.
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