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目的观察预防性持续低剂量咖啡因在超低出生体质量儿呼吸暂停治疗中的临床疗效。方法将超低出生体质量儿208例随机分为试验组和对照组各104例。试验组患儿在出生后尚未发生呼吸暂停时给予持续低剂量咖啡因治疗,对照组患儿在发生呼吸暂停后才开始接受咖啡因治疗。比较并评价2组患儿治疗效果。结果试验组在患儿出生1周内呼吸暂停发生率和体质量增至2.0kg前呼吸暂停发生率均低于对照组,差异均有统计学意义(P<0.05)。试验组反复发生呼吸暂停而使用呼吸机的百分率低于对照组,差异有统计学意义(P<0.05)。结论持续低剂量咖啡因用于预防超低出生体质量儿呼吸暂停,能够有效缓解患儿的病症。
Objective To observe the clinical efficacy of prophylactic continuous low-dose caffeine in the treatment of neonatal asthma with ultra-low birth weight. Methods A total of 208 children with ultra-low birth weight were randomly divided into experimental group and control group (n = 104). Children in the experimental group were given continuous low-dose caffeine after apnea did not occur after birth, and children in the control group did not receive caffeine until their apnea occurred. Compare and evaluate the treatment effect of two groups of children. Results The incidence of apnea in the experimental group within 1 week after birth and the incidence of apnea before the body mass increased to 2.0 kg were lower than those in the control group, with statistical significance (P <0.05). The percentage of recurrent apnea and ventilator used in the experimental group was lower than that of the control group (P <0.05). Conclusions Continuous low-dose caffeine is used to prevent apnea of ultra-low birth weight children and can effectively alleviate the symptoms of children.