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目的:观察不同剂量丙种球蛋白治疗川崎病的临床效果。方法:选取2008年3月～2012年9月笔者所在医院收治的川崎病患者42例,将其随机分为A组和B组,各45例,A组采用丙种球蛋白2g/kg治疗,B组采用丙种球蛋白400mg/kg治疗,其余治疗方法两组均相同。观察两组治疗后退热和急性期症状消退时间,应用丙种球蛋白的不良反应及冠脉损害的出现率。结果:B组临床症状改善较慢,退热时间、黏膜充血、皮疹消退时间、手足肿胀、淋巴结炎消退时间较A组明显较长(P<0.01);治疗前两组CAL发生率分别为:B组1例为6.67%,A组0例。经治疗两组均无新增病例。结论:单次大剂量丙种球蛋白治疗川崎病可明显改善临床症状,降低冠状动脉病变发生率。
Objective: To observe the clinical effect of different doses of gamma globulin in treating Kawasaki disease. Methods: Forty-two patients with Kawasaki disease who were admitted to our hospital from March 2008 to September 2012 were randomly divided into group A and group B (n = 45), group A received treatment with gamma globulin 2 g / kg, group B Group using gamma globulin 400mg / kg treatment, the remaining treatment methods are the same in both groups. Two groups were observed after treatment fever and acute symptoms subsided time, the application of gamma globulin adverse reactions and the incidence of coronary lesions. Results: The improvement of clinical symptoms in group B was slower than that in group A (P <0.01). The onset of fever, mucosal hyperemia, rash subsidence time, hand-foot swelling and lymphadenitis were significantly longer than those in group A (P <0.01) 1 patient in group B had 6.67%, and 0 patient in group A. After treatment, no new cases were found in both groups. Conclusion: A single high-dose gamma globulin treatment of Kawasaki disease can significantly improve the clinical symptoms and reduce the incidence of coronary artery disease.