慢性肝病时,“疾病的进展”意味着各个器官的损害通过共同的发展过程,演变为纤维化和肝硬化:如图1所示。细胞坏死是反应链的开始,最终导致肝硬化和肝功能丧失。此过程涉及到肝细胞持续的再生反应,枯否细胞、窦旁贮脂(Ito)细胞以及游走的单核细胞也参与其中。肝细胞或者在直接受损后崩解,或者成为淋巴细胞的免疫攻击目标。受损的肝细胞表面 HLA 分 In chronic liver disease, “progression of the disease” means that the damage of various organs evolves into fibrosis and cirrhosis through a common developmental process: Figure 1 shows. Cell necrosis is the beginning of the reaction chain, eventually leading to cirrhosis and loss of liver function. This process involves the sustained regeneration of hepatocytes, and Kupffer cells, Ito cells and migratory monocytes are also involved. Liver cells either collapsed directly after they were damaged, or became the target of immune attack by lymphocytes. Impaired liver cell surface HLA score