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Lomefloxacin(LFLX)是一种新的喹诺酮抗菌剂,其结构特点是哌嗪环3位上有一个甲基。据报道,喹诺酮类衍生物的血清蛋白结合率与它们分子中喹诺铜环7位取代基体积的大小有关,取代基大的化合物如氟啶酸(ENX)、甲氟哌酸(PFLX)的血清蛋白结合率较低(20%～35%);取代基小的如
Lomefloxacin (LFLX) is a novel quinolone antibacterial agent characterized by the presence of a methyl group at the 3-position of the piperazine ring. It has been reported that the binding rates of serum proteins of quinolone derivatives are related to the size of their quinone ring 7 substituents in their molecules. Substituents with large substituents such as nifedipine (ENX), norfloxacin (PFLX) Serum protein binding rate is low (20% ~ 35%); Substituent small as