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目的:探讨氨苯砜(DDS)综合征误诊原因和临床治疗特点。方法:报告2例氨苯砜综合征误诊病例。结果:2例首诊均误诊。1例先后误诊为上呼吸道感染、发热待查;1例误诊为肝功能损害待查。结论:DDS综合征的临床特征为发热、皮疹、黄疸、淋巴结肿大、贫血及肝脏损害等,确诊主要依靠DDS用药史。其治疗遵循重症药疹的治疗原则。糖皮质激素开始应用足量,减量不宜过多、过快。
Objective: To investigate the causes of misdiagnosis and clinical treatment of dapsone syndrome. Methods: Two cases of misdiagnosis of dapsone syndrome were reported. Results: 2 cases of first diagnosis were misdiagnosed. One case had been misdiagnosed as upper respiratory tract infection, fever to be investigated; one case misdiagnosed as liver dysfunction pending investigation. Conclusion: The clinical features of DDS syndrome are fever, rashes, jaundice, lymphadenopathy, anemia and liver damage. The diagnosis depends on the history of DDS medication. The treatment followed the principle of treatment of severe drug eruption. Glucocorticoids began to apply enough weight reduction should not be too much, too fast.