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为了探讨肾移植术后尿中前列腺素的变化及其临床意义，我们测定了３４例肾移植术后患者（其中１１例伴有急性排异反应）、１６例尿毒症患者尿中前列腺素的变化。结果显示，肾移植术后尿中６－ｋｅｔｏＰＧＦ１α（６－酮前列腺素Ｆ１α）降低，ＴＸＢ２（血栓素Ｂ２）增高，随着肾功能的改善，二者均渐恢复正常。急性排异反应者尿６－ｋｅｔｏＰＧＦ１α降低及ＴＸＢ２升高更为显著，尤其是ＴＸＢ２较肌酐升高早而显著，并随着排异反应的控制而降低。上述结果表明，尿中前列腺素的变化，尤其是ＴＸＢ２的变化是监测肾移植早期排异反应的较好指标。
In order to explore the changes of urinary prostaglandins after renal transplantation and its clinical significance, we measured the changes of urinary prostaglandins in 34 patients with renal transplantation (11 with acute rejection) and 16 with uremia . The results showed that urinary 6-ketoPGF1α (6-ketoprostaglandin F1α) and TXB2 (thromboxane B2) were decreased after renal transplantation. Both of them returned to normal with renal function improvement. Acute rejection of urinary 6-ketoPGF1α decreased and TXB2 increased more significantly, especially TXB2 earlier than the creatinine increased significantly, and with the reduction of rejection control. The above results indicate that changes in urinary prostaglandins, especially TXB2, are good indicators for monitoring the early rejection of renal transplantation.