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Objective:To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells(MSCs) of osteoporosis rat.Methods:MSCs were obtained from osteoporosis rat,and proliferation potency and impaired osteogenic differentiation potential were determined.Results:The result showed a significant downregulation of MSCs pluripotency related gene(Oct4) and osteogenic genes(BSP,OCN) expression in OVX MSCs compared with Sham MSCs(P<0.05).Conclusions:These data suggest that MSCs are aging in osteoporosis body,and autologous OVX MSCs transplantation is not appropriate to treat osteoporosis if necessary.There will be a possibility in establishing a new clinical application of MSCs autologous transplantation to treat osteoporosis,if OVX MSCs have stronger proliferation and differentiation.
Objective: To explore "Susceptibility to proliferative differentiation and differentiation potential of mesenchymal stem cells (MSCs) of osteoporosis rat. Methods: MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined. Results: The result showed a significant downregulation of MSCs were compared with Sham MSCs (P <0.05) .Conclusions: These data suggest that MSCs are aging in osteoporosis bodies, and autologous OVX MSCs transplantation is not appropriate to treat osteoporosis if necessary. It will be a possibility in establishing a new clinical application of MSCs autologous transplantation to treat osteoporosis, if OVX MSCs have reinforced proliferation and differentiation.