论文部分内容阅读
目的:探讨卵巢癌患者外周血T淋巴细胞亚群与各临床病理指标相关变化及意义。方法:采用流式细胞术(FCM)对61例恶性卵巢肿瘤(原发肿瘤53例,转移性肿瘤8例)患者术前进行外周血T淋巴细胞亚群检测,并与28例健康妇女进行定量比较分析。同时就原发性卵巢癌与各临床病理因素进行统计学分析。结果:53例上皮性卵巢癌及8例转移性恶性卵巢肿瘤T淋巴细胞亚群中CD8+明显高于健康对照组(P<0.01),CD3+、CD4+、CD4+/CD8+均明显低于健康对照组(P<0.05或P<0.01)。肿瘤患者外周血T淋巴细胞变化与年龄、癌块大小、腹水量、组织分化程度、FIGO临床分期、CA125水平有关,但与组织类型无关。结论:恶性卵巢肿瘤患者T淋巴细胞免疫功能受到明显抑制,且与早期诊断及预后相关的临床病理指标有密切联系。
Objective: To investigate the changes of peripheral blood T lymphocyte subsets and clinicopathological parameters in patients with ovarian cancer and its significance. Methods: Peripheral blood T lymphocyte subgroups were detected in 61 patients with malignant ovarian tumors (primary tumors and 8 metastases) by flow cytometry (FCM) and quantified with 28 healthy women comparative analysis. At the same time, the primary ovarian cancer and each clinicopathological factors were statistically analyzed. Results: The CD8 + T lymphocyte subsets in 53 cases of epithelial ovarian cancer and 8 cases of metastatic malignant ovarian tumor were significantly higher than those in the healthy control group (P <0.01), and the levels of CD3 +, CD4 +, CD4 + / CD8 + were significantly lower than those in the healthy control group P <0.05 or P <0.01). The changes of T lymphocytes in peripheral blood of patients with cancer were related to age, size of cancer, amount of ascites, degree of tissue differentiation, FIGO clinical stage and CA125 level, but not with tissue type. CONCLUSION: The immune function of T lymphocytes in patients with malignant ovarian tumors is significantly inhibited, and it is closely related to the clinicopathological features of early diagnosis and prognosis.