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棕曲霉毒素A(Ochratoxin A)是一种毒性代谢物,并从好几种曲霉系群、斑纹纯绿青霉菌(P.Viridicatum)和2种霉菌分离出来。这些霉菌污染的粮食和饲料,查出含棕曲霉毒素高达27 ppm。一些作者曾先后用大鼠、小鸭等研究棕曲霉毒素A的急性毒性,发现半数致死量上、下的剂量能使动物产生肾和肝的变化。作者在经口或皮下给药的慢性实验中未发现有致癌作用。棕曲霉毒素A在公共卫生上的潜在作用,首先由动物(如猪)经霉菌诱致中毒的研究而引起注意。以后由于黄曲霉毒素导致肝癌的可能作用而引起注意。最近在巴
Ochratoxin A is a toxic metabolite isolated from several Aspergillus species, P. viridicatum and two molds. These mildew-contaminated foodstuffs and feedstuffs contain as much as 27 ppm of as-contained aflatoxins. Some authors have used rat, duckling and other acute toxicities of arachidonic toxin A and found that the dose of upper and lower lethal dose can cause changes of kidney and liver in animals. The authors did not find any carcinogenic effects in chronic oral or subcutaneous administration. The potential role of tetrodotoxin A in public health is first noticed by research on mold-induced poisoning of animals such as pigs. Later due to aflatoxin liver cancer may lead to the possible role of attention. Recently in Pakistan