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以循环内皮细胞（ＣＥＣ）作为血管内皮细胞（ＶＥＣ）损伤的指示物，以血浆内皮素（ＥＴ）和前列环素（ＰＧＩ２）反映ＶＥＣ的功能变化，对８５例冠心病患者与３０例正常人进行对比研究，并对５０例不稳定型心绞痛及２０例急性心肌梗塞进行了动态观察．结果表明：冠心病外周血中ＣＥＣ、ＥＴ明显升高（Ｐ＜０．００１），ＰＧＩ２明显下降（Ｐ＜０．００１），尤以不稳定型心绞痛和急性心肌梗塞更显著，与病情的严重程度相一致．提示冠心病ＶＥＣ损伤，以及它所分泌的内皮源性舒缩因子失平衡参与了冠心病的病理过程。
Using circulating endothelial cells (CECs) as an indicator of vascular endothelial cell (VEC) injury, VEC functional changes were evaluated by plasma endothelin (ET) and prostacyclin (PGI2). Eighty-five patients with coronary heart disease and 30 normal controls 50 patients with unstable angina and 20 patients with acute myocardial infarction were observed. The results showed that the levels of CEC, ET in peripheral blood of patients with coronary heart disease were significantly higher (P <0.001) and PGI2 was significantly lower (P <0.001), especially unstable angina pectoris and acute myocardial infarction were more significant The same extent. Suggesting that VEC injury of coronary heart disease, as well as the imbalance of endothelium-derived contraction and contraction factor secreted by it, are involved in the pathological process of coronary heart disease.