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目的：研究冠状动脉（冠脉）内弹力膜缺损与内膜增厚及动脉粥样硬化发生发展的关系。方法：应用图像分析仪对北京地区１０２例意外死亡年轻人（１５～３９岁）冠脉近侧端进行了形态定量及统计学处理。结果：在同体三支冠脉的比较中内弹力膜缺损程度以左前降支居首位，其次为右冠脉和左旋支。男重于女。内弹力膜缺损程度与内膜增厚呈正相关（ｒ＝０．８７，Ｐ＜０．０１）。紧接内膜增厚高峰之后的年龄组第二弹力膜检出率最高，此后十年间内膜亦无明显进一步增厚。随年龄增长第二弹力膜检出率降低，内膜增厚程度加重。结论：内弹力膜缺损的量与内膜增厚的程度及速度关系密切；第二弹力膜的形成对减慢内膜增厚速度有重要意义。
Objective: To study the relationship between the defect of coronary artery (coronary artery) elastic membrane and the intimal thickening and the development of atherosclerosis. Methods: 102 cases of accidental death in Beijing area (15 ~ 39 years old) coronary artery proximal end morphology and quantitative analysis using image analyzer. Results: Compared with the three coronary arteries, the extent of the defect of the internal elastic membrane was predominant in the left anterior descending artery, followed by the right coronary artery and the left circumflex artery. Men are heavier than women. There was a positive correlation between the extent of internal elastic membrane defect and intimal thickening (r = 0.87, P <0.01). Immediately after the peak of intima-media thickness, the highest percentage of the second membrane was found in the age group, and no significant thickening of the intima occurred within 10 years. With age, the detection rate of the second stretch membrane decreased, the degree of intimal thickening increased. CONCLUSION: The amount of internal elastic membrane defect is closely related to the extent and speed of intimal thickening. The formation of the second elastic membrane is of great importance to slow the intimal thickening rate.