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目的:确定广西壮汉族正常足月新生儿生后1～7天血清胆红素的动态变化值,为临床诊断奠定基础。方法:①用微量法测定广西地区正常足月新生儿生后第1～7天血清胆红素,分别记录其测定值。②应用生化法与微量法相结合方法,即用静脉生化法与微量法同步测定72例新生儿血清胆红素,用微量法测定值代入生化法与微量法测定值建立的直线回归方程,获取胆红素校正值。结果:①正常足月新生儿1～7天血清胆红素分别为(72.17±14.39)μmol/L、(128.93±28.92)μmol/L、(174.69±33.07)μmol/L、(186.46±34.23)μmol/L、(174.25±37.60)μmol/L、(154.49±42.76)μmol/L、(141.41±44.97)μmol/L,平均峰值(186.46±34.23)μmol/L。②壮族新生儿血清胆红素平均峰值比汉族略高,壮汉两族1～7天血清胆红素的比较差异无统计学意义(P>0.05)。③微量法与静脉生化法胆红素测定值有高度的相关性,两法测定值比较差异无统计学意义(P>0.05);校正后的胆红素值与静脉生化法测定值比较,差异无统计学意义(P>0.05)。结论:广西地区壮汉族足月新生儿生理性黄疸生后1～7天血清胆红素动态变化值,为临床对新生儿黄疸的合理干预提供科学依据。生化法与微量法相结合的方法测定血清胆红素准确、便捷,是一种动态监测新生儿血清胆红素的理想方法。
Objective: To determine the dynamic change of serum bilirubin in normal full-term newborns of Guangxi Zhuang nationality from 1 to 7 days after birth to lay the foundation for clinical diagnosis. Methods: (1) Serum bilirubin of normal full-term newborns in Guangxi area was measured by microtome method on the 1st to 7th day after birth, and the measured values were recorded respectively. ② The biochemical method combined with the trace method was used to determine the serum bilirubin in 72 neonates synchronously by the method of intravenous biochemistry and microtome. The linear regression equation was established by the trace method and the biochemical method and the trace method. Red correction value. Results: ① Serum bilirubin in normal term neonates from 1 to 7 days was (72.17 ± 14.39) μmol / L, (128.93 ± 28.92) μmol / L, (174.69 ± 33.07) μmol / L and (186.46 ± 34.23) (174.25 ± 37.60) μmol / L, (154.49 ± 42.76) μmol / L and (141.41 ± 44.97) μmol / L, respectively. The average peak value was (186.46 ± 34.23) μmol / L. ② The mean serum bilirubin peak value of newborns in Zhuang nationality was slightly higher than that of Han nationality group. There was no significant difference in serum bilirubin between 1 and 7 days in Zhuang and Han nationality (P> 0.05). (3) There was a high degree of correlation between micro-method and intravenous biochemical determination of bilirubin, and there was no significant difference between the two methods (P> 0.05); the corrected bilirubin value was significantly lower than that of intravenous biochemical method No statistical significance (P> 0.05). Conclusion: The dynamic changes of serum bilirubin levels in neonates with full-term newborn infants with physical jaundice 1 ~ 7 days after birth in Guangxi may provide a scientific basis for reasonable intervention of neonatal jaundice. Biochemical method combined with trace determination of serum bilirubin method is accurate and convenient, is an ideal method for dynamic monitoring of neonatal serum bilirubin.