论文部分内容阅读
实验研究了胺甲硫磷在急性、亚慢性染毒时对大鼠血、脑乙酰胆碱酯酶（AchE）的影响，及在体外条件下，以人红细胞膜制备物为对象，脸甲硫磷抑制AchE的机理。结果表明，胺甲硫磷不仅在急性染毒时（1／10LD(50)）对血、脑AchE有抑制作用，而且当亚慢性（90d）染毒时，高剂量组（在1／25LD_(50)剂量下）对血、脑AchE也有抑制作用。体外试验表明，胺甲硫磷对人红细胞膜AchE的抑制作用具有剂量效应和时间效应关系，对AchE的抑制作用为不可逆性，其双分子速率常数较小，符合硫酮式有机磷化合物作用规律。
The effects of methiophos on the blood and brain acetylcholinesterase (AchE) in rats after acute and subchronic exposure were studied experimentally, and the inhibitory effects of methionine on human erythrocyte membrane preparations AchE mechanism. The results showed that methionine not only inhibited the blood and brain AchE in acute exposure (1 / 10LD (50)), but also in the high dose group (1 / 25LD_ ( 50) dose) on the blood, brain AchE also inhibited. In vitro experiments showed that methionine on human erythrocyte membrane AchE inhibition has a dose-effect and time-dependent, the inhibition of AchE is irreversible, the bimolecular rate constant smaller, consistent with the role of thione ketone organophosphorus compounds .