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金属配合物和有机小分子双体系联合催化的不对称接力催化反应是一新兴热点研究领域.接力催化可以由易得的起始原料生成结构复杂的化合物,实现单一催化剂无法实现的新反应,并且避免了对不稳定中间体的分离纯化,提高了反应的步骤经济性和原子经济性.手性磷酸是近年来研究最为热门的有机小分子催化剂之一,其与金属催化剂结合催化也得到了深入的研究.本工作即针对金属催化剂和手性磷酸结合的接力催化反应的研究进展,做一简要评述.
Catalytic asymmetric catalysis catalyzed by metal complexes and organic small molecule systems is a new and hot area of research. Relay catalysis can generate complex compounds from readily available starting materials and achieve new reactions unattainable by single catalysts, and Which avoids the separation and purification of unstable intermediates and improves the step economy and atomic economy of the reaction.Chiral phosphoric acid is one of the most popular organic small molecule catalysts in recent years and has also been deeply catalyzed by metal catalysis This work is about the metal catalyst and chiral phosphate binding reaction catalysis progress, make a brief review.