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目的:探讨葡萄糖酸锌应用于小儿轮状病毒性肠炎的临床疗效。方法:将116例轮状病毒性肠炎患儿随机分为对照组与观察组,两组患儿均接受抗病毒及补液等常规治疗。观察组患者同时给予葡萄糖酸锌口服,比较两组临床疗效及治疗前后心肌酶谱的改变。结果:观察组治疗有效率显著高于对照组(P<0.05);观察组患儿止泻时间、脱水纠正时间及退烧时间显著早于对照组(P<0.05);治疗前两组天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)及同工酶(CK-MB)无显著差别,治疗后观察组患儿上述指标显著优于对照组(P<0.05),差异有统计学意义。结论:葡萄糖酸锌应用于小儿轮状病毒性肠炎可提高临床疗效,促进病情恢复。
Objective: To investigate the clinical efficacy of zinc gluconate in pediatric rotavirus enteritis. Methods: One hundred and sixty-one children with rotavirus enteritis were randomly divided into control group and observation group. Both groups received routine treatment such as antivirus and rehydration. The patients in the observation group were given oral zinc gluconate at the same time. The clinical efficacy and myocardial enzyme changes before and after treatment were compared between the two groups. Results: The treatment efficiency in the observation group was significantly higher than that in the control group (P <0.05). The antidiarrheal time, dehydration correction time and fever relief time in the observation group were significantly earlier than those in the control group (P <0.05) There was no significant difference in the levels of AST, LDH, CK and MB between the two groups. The above indexes in the observation group were significantly better than those in the control group (P <0.05), the difference was statistically significant. Conclusion: The application of zinc gluconate in children with rotavirus enteritis can improve the clinical efficacy and promote the recovery of the disease.