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目的：分析血管活性物质在高血压出血性脑卒中术后高血压危象中的作用。方法：将２２例高血压脑出血患者分为高血压出血性脑卒中术后高血压危象组（Ａ组）９例，高血压出血性脑卒中术后无高血压危象组（Ｂ组）１３例。以同期非出血性脑卒中的颅脑手术患者作为对照组（Ｃ组）９例，分别测定几种血管活性物质含量或活性。结果：①Ａ组患者内皮素、凝血烷Ｂ２（血栓素Ｂ２，ＴＸＢ２）、前列环素（ＰＧＩ２）和去甲肾上腺素的含量及ＴＸＢ２／ＰＧＩ２明显高于Ｂ、Ｃ组患者。②Ａ组患者去甲肾上腺素术后明显高于术前，Ｐ＜００１。结论：ＴＸＢ２／ＰＧＩ２值增加以及内皮素、去甲肾上腺素的含量增高对术后高血压危象的发生有一定作用
Objective: To analyze the role of vasoactive substances in hypertensive crisis after hemorrhagic stroke in hypertensive patients. Methods: Twenty-two patients with hypertensive intracerebral hemorrhage were divided into three groups: hypertensive hemorrhagic stroke postoperative hypertensive crisis group (group A), hypertensive hemorrhagic stroke without hypertensive crisis group (group B) 13 cases. In the same period non-hemorrhagic stroke in patients with craniocerebral surgery as a control group (C group) 9 cases, were measured in several vasoactive substances content or activity. Results: ① The levels of endothelin, thromboxane B2 (TXB2), prostacyclin (PGI2) and norepinephrine and TXB2 / PGI2 in group A were significantly higher than those in groups B and C. ②A group patients norepinephrine was significantly higher than preoperative, P <0 01. Conclusions: The increase of TXB2 / PGI2 and the increase of endothelin and norepinephrine may play a role in the postoperative hypertensive crisis