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致癌物在生物体内经解毒系统诱导与生物体内的DNA形成加合物,DNA加合物综合反映了生物体对致癌物的暴露、吸收、分布、代谢以及机体对DNA的修复能力,是致癌物有效作用的量度,与致癌作用直接相关。目前较多用于DNA加合物测定的方法是~(32)P后标记技术。DNA加合物作为一项反映人群暴露于致癌物的指标在肿瘤分子流行病学研究中得到了较好的应用,鱼与哺乳动物一样可活化致癌物形成DNA加合物,由于解毒系统不完善及DNA修复能力差而对致癌物特别敏感,因此鱼及其他水生动物的DNA加合物研究受到重视并且一直引人注目。
Carcinogens in the body by the detoxification system induction and DNA in vivo formation of adducts, DNA adducts comprehensively reflect the organism’s exposure to carcinogens, absorption, distribution, metabolism and the body’s ability to repair DNA is carcinogenic A measure of the useful effect, directly related to carcinogenicity. At present, the most used method for the determination of DNA adducts is the ~ (32) P post-labeling technique. DNA adducts, as an indicator of population exposure to carcinogens, are well used in tumor molecular epidemiology studies. Fish, like mammals, can activate carcinogens to form DNA adducts. Due to the imperfect detoxification system And DNA repair ability is poor and carcinogens are particularly sensitive, so fish and other aquatic animal DNA adduct study has been attention and has been attracting attention.