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目的 :了解 6 8例晚期大肠癌采用单纯FOM方案静脉化疗和局部注射联合FOM方案治疗的近期疗效、生存率、毒副反应等。方法 :随机分为治疗组 (局部注射联合FOM方案组 ) 36例 ,对照组 (单用FOM方案组 )32例 ,记录观察近期疗效、毒副反应、随访并计算生存期 ,采用Kaplan -Meier法估计生存函数 ,Logrank检验两组生存函数差异。结果 :对照组总有效率 37.5 % ,中位生存期为 10 .3个月 ;治疗组总有效率 5 2 .8% ,中位生存期为 18.6个月 ;两组总有效率和中位生存率差异显著 (P <0 .0 5 ) ;而两组毒副反应无显著差异 (P >0 .0 5 )。结论 :局部注射联合POM方案治疗晚期大肠癌明显提高有效率和生存质量 ,延长了患者的生存期 ,且毒副反应小无明显增加。
OBJECTIVE: To investigate the short-term curative effect, survival rate and toxicity of 68 cases of advanced colorectal cancer treated with simple FOM regimen and local injection combined with FOM regimen. Methods: Thirty-six cases were randomly divided into treatment group (FOM group) and control group (FOM group alone group). 32 patients were treated with FOM regimen. The curative effect, side effects and follow-up were observed and recorded. Kaplan-Meier method Estimated survival function, Logrank test differences in survival function between the two groups. Results: The total effective rate was 37.5% in the control group and the median survival time was 10.3 months. The total effective rate was 52.8% in the treatment group and 18.6 months in the control group. The total effective rate and median survival rate The difference was significant (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: The combination of local injection and POM regimen can significantly improve the efficiency and quality of life of patients with advanced colorectal cancer, prolong the survival of patients, and no significant increase in toxicity.