论文部分内容阅读
作者对295例肝疾病患者(55例肝炎,192例肝硬化,48例肝癌)和710例正常对照者进行了转铁蛋白(Transferrin,Tf)C亚型检测。结果表明:肝炎、肝硬化及肝癌与正常对照组之间Tf表型分布及基因频率无显著性差异。研究发现,在肝癌患者中,携带Ff~*C2基因的个体同正常健康人相比显著地增多,x~2=4.5456,P<0.050。经Woolf及Haldane相关性检验,发现TfC1C2表型与患肝癌有关联,RI=1.9410,P<0.025。男性患肝癌与FfC1C2表型也相关,RI=1.9547,P<0.050。Hardy-Weinberg吻合度检验结果,3种疾病的观察值与期望值均相符。
The authors tested transferrin (Tf) C subtypes in 295 liver disease patients (55 hepatitis, 192 cirrhosis, 48 hepatocellular carcinoma) and 710 normal controls. The results showed that there was no significant difference in the distribution of Tf phenotypes and the frequency of genes between hepatitis, cirrhosis, hepatocellular carcinoma and normal controls. The study found that, in patients with liver cancer, individuals carrying Ff ~ * C2 gene significantly increased compared with normal healthy people, x ~ 2 = 4.5456, P <0.050. The Woolf and Haldane correlation test showed that TfC1C2 phenotype was associated with liver cancer, RI = 1.9410, P <0.025. Male patients with liver cancer and FfC1C2 phenotype is also related, RI = 1.9547, P <0.050. Hardy-Weinberg agreement test results, the observed value of the three diseases and expectations are consistent.