免疫系统在维持对自身耐受的同时,必须识别外来病原等异己物质,此种识别功能的敏感性和特异性很大程度上有赖于Toll样受体(Toll-like receptors,TLRs)的表达。TLRs是高度保守的转膜蛋白,能识别内、外源性配体而参与先天与获得性免疫应答,TLRs启动的炎性信号通路及其诱导分泌的 The immune system must recognize foreign pathogens and other foreign substances while maintaining its own tolerance. The sensitivity and specificity of this recognition function depend largely on the expression of Toll-like receptors (TLRs). TLRs are highly conserved transmembrane proteins that recognize endogenous and exogenous ligands and participate in innate and adaptive immune responses. TLRs initiate inflammatory signaling pathways and induce secretion