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临床上进行心脏手术时，患者机体应激反应强，容易造成损伤。目前抑制此类手术所致应激反应主要应用的是大剂量的阿片类药物。舒芬太尼镇痛作用强，应用后血流动力学较平稳，具有较小的心功能影响和抑制呼吸作用，近几年来逐渐广泛地应用于先天性心脏病、瓣膜置换术以及冠状动脉旁路移植术等心脏手术的麻醉中。将阿片类受体药物合理有效地应用于心脏外科手术的麻醉中在围术期间发挥了举足轻重的作用。“,”In clinical during heart surgery,patient stress response is strong,which is likely to cause dam-age.At present,large doses of opioids are mainly used to inhibit the operation induced stress response.Sufen-tanil has strong analgesic effect,after the application hemodynamic is relatively stable,with a smaller influ-ence on heart function and respiration inhibition,which is being increasingly used in the anesthesia of cardiac surgeries such as congenital heart disease,coronary valve replacement and coronary artery bypass grafting. Application of opioid receptor drugs reasonably and effectively in cardiac surgery anesthesia has played an important role during the peri-operation.