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选择１２７名ＴＰＡ作业工人进行动式个体采样，并留取１２７名ＴＰＡ作业工人当日工前工后尿样和７０名对照工人的工前尿。对尿样中γ谷氨酰转肽酶（ＧＧＴ）、碱性磷酸酶（ＡＬＰ）、乳酸脱氢酶（ＬＤＨ）、Ｎ乙酰βＤ氨基葡糖苷酶（ＮＡＧ）活性以及尿ＴＰＡ、α１微球蛋白（α１ＭＧ）、β２微球蛋白（β２ＭＧ）水平进行分析。结果显示，ＴＰＡ接触组尿ＧＧＴ、ＡＬＰ、ＬＤＨ、ＮＡＧ活性以及尿α１ＭＧ、β２ＭＧ水平与对照组相比无显著差别，而５～ｍｍｏｌ／ｍｏｌ．Ｃｒ尿ＴＰＡ负荷组工人尿β２ＭＧ与对照组相比有明显升高（Ｐ＜００５），尿β２ＭＧ与尿ＴＰＡ负荷量呈现一定的剂量依赖关系。尿ＴＰＡ水平对尿酶活性、α１ＭＧ均未产生明显影响。不同累积接尘量和不同工龄的工人尿酶和微球蛋白无明显差异。提示ＴＰＡ对肾实质可造成一过性可逆性影响，尚不能说明肾实质受到器质性损伤。
A total of 127 TPA workers were selected for dynamic individual sampling. Pre-work-up urine samples of 127 TPA workers on the same day and pre-operative urine of 70 control workers were collected. In urine samples, γ-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), NacetylβDglucosaminidase (NAG) TPA, α1 microglobulin (α1 MG), β2 microglobulin (β2 MG) levels were analyzed. The results showed that urinary GGT, ALP, LDH, NAG urinary excretion of urinary α1MG and β2MG in TPA exposure group had no significant difference compared with the control group, while 5mmol / mol. Cr urinary TPA stress group workers urine β2 MG compared with the control group was significantly higher (P <0 05), urinary β2 MG and urinary TPA load showed a dose-dependent manner. Urinary TPA levels of urease activity, α1 MG did not have a significant effect. There was no significant difference in urinary enzyme and microglobulin between workers with different accumulated dust exposure and different working ages. Tip TPA on the renal parenchyma can cause a transient reversible effect, still can not explain the renal parenchyma by organic damage.