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消化系统肿瘤对化学治疗的敏感性较低，对于不适合手术治疗的中晚期肿瘤或复发肿瘤患者，大剂量化学治疗的效果尚不理想，且患者的生存质量较差。因此积极地开发有效的抗癌药物，探索新的给药途径是消化系统肿瘤化学治疗的重要研究课题。根据Biochemicalmodulation理论，采用联
Digestive system tumors are less sensitive to chemotherapy. For patients with advanced or recurrent tumors who are not suitable for surgical treatment, the effect of high-dose chemotherapy is not satisfactory and the quality of life of the patients is poor. Therefore, active development of effective anticancer drugs, explore new routes of administration is an important research topic in the chemotherapy of digestive system tumors. According to Biochemicalmodulation theory, the use of joint