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目的 研究小剂量 β 受体阻滞剂对急性心肌梗死患者心率变异的影响。 方法 44例急性心肌梗死患者入院后随机分为 β 受体阻滞剂治疗组 ( 18例 )和对照组 ( 2 6例 )。治疗组于即刻给予氨酰心安 ( 12 .5～ 2 5mg d)或美多心安 ( 2 5～ 5 0mg d) ,余治疗相同。 10～ 14d后行 2 4h动态心电图检查 ,分析心率变异的时域指标SDNNSDANNrMSSDPNN5 0、散点图指标VLIVAI的变化。用配对t检验进行统计学处理。结果 早期使用小剂量 β 受体阻滞剂可使急性心肌梗死患者的心率变异的时域指标、散点图指标均有显著增加。进一步研究发现 ,这种改善作用在前壁与下壁急性心肌梗死之间差异无显著性。结论 对急性心肌梗死患者早期使用 β 受体阻滞剂可显著改善患者的心率变异 ,这种作用在前壁心肌梗死与下壁心肌梗死之间差异无显著性
Objective To study the effect of low-dose β-blocker on heart rate variability in patients with acute myocardial infarction. Methods Forty-four patients with acute myocardial infarction were randomly divided into β-blocker treatment group (18 cases) and control group (26 cases). Patients in the treatment group were treated with atenolol (12.5 to 25 mg) or metoprolol (25 to 50 mg) immediately after the same treatment. After 10 ~ 14d 24 h ambulatory ECG examination, heart rate variability analysis of the time domain index SDNNSDANNrMSSDPNN50, scatter plots VLIVAI changes. Paired t-test was used for statistical analysis. Results Early use of low-dose β-blocker could significantly increase the heart rate variability in patients with acute myocardial infarction. Further study found that this improvement in the anterior wall and inferior wall acute myocardial infarction was no significant difference between. Conclusion Early use of β-blockers in patients with acute myocardial infarction can significantly improve the patient’s heart rate variability, this effect was no significant difference between anterior myocardial infarction and inferior myocardial infarction