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目的探讨ｐ５３蛋白在喉癌中的表达特征及其临床意义。方法采用抗ｐ５３蛋白的单克隆抗体，通过ＬＳＡＢ免疫组化技术，对７１例喉癌进行了研究。结果全组病例中喉癌组织ｐ５３蛋白阳性率为６４．８％（４６／７１），而声带小结表达率仅５．０％（１／２０），两者比较差异显著（Ｐ＜０．０５）。研究还发现，ｐ５３蛋白表达与喉癌，淋巴结转移有显著的相关性。结论采用免疫组化技术检测ｐ５３蛋白的异常表达，可作为临床选择治疗方案以及判断预后的有效手段之一。
Objective To investigate the expression of p53 protein in laryngeal carcinoma and its clinical significance. Methods 71 cases of laryngeal cancer were studied by LSAB immunohistochemistry using anti-p53 monoclonal antibody. Results The positive rate of p53 protein in laryngeal carcinoma tissues was 64.8% (46/71) in all the cases and only 5.0% (1/20) in vocal nodules, with significant difference between the two groups (P <0.05 ). The study also found that p53 protein expression and laryngeal cancer, lymph node metastasis was significantly correlated. Conclusions Using immunohistochemistry to detect the abnormal expression of p53 protein may be one of the effective methods to choose the treatment regimen and prognosis.