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采用致癌物质诱发动物以建立肿瘤模型,是探索肿瘤病因,验证各种发病因素,开展肿瘤实验治疗,进行药物定向筛选以及研究癌变理论的常用手段之一,这在人类肿瘤防治的研究中具有非常重要的意义(1),1967年杉村等将N甲基N~1硝基N亚硝基胍,(N—methy—N—nitroso—N′—nitroguanidine,简称MNNG)用于实验性胃癌的研究,成功地诱发了大鼠的腺胃胃癌,且在解剖组织学上都与人类胃癌相似,并具有以下优点:
The use of carcinogenic substances to induce animals to establish a tumor model is one of the commonly used means to explore the etiology of the tumor, to verify a variety of risk factors, to carry out the experimental treatment of cancer, to screen the drug targets and to study the theory of canceration, which is very unusual in the study of human tumor prevention and treatment Significance (1) In 1967 Sugimura et al. Used N-methyl-N-nitrosoguanidine (N-methy-N-nitroso-N’-nitroguanidine, MNNG for short) , Successfully induced gastric adenocarcinoma in rats and is anatomically similar to human gastric carcinoma with the following advantages: