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目的探讨小儿特发性血小板减少性紫癜与病毒感染的关系。方法细小病毒B19检测:采用多聚合酶链反应(PCR),试剂盒购自华美工程公司,其余均采用酶联免疫吸附试验。结果42例ITP患者进行了巨细胞病毒抗体的检测,其中5例阳性,阳性率为12%,62例ITP患者进行了EB病毒抗体的检测,其中6例阳性,阳性率为10%,70例患者进行了细小病毒B19的检测,其中30例阳性,阳性率约为43%。30例ITP患者进行了单疱病毒Ⅰ型及Ⅱ型抗体的检测,阳性率为27%,其中单疱病毒Ⅰ型抗体阳性者为7例,1例为单疱病毒Ⅱ型抗体阳性。30例ITP患者进行了风疹病毒抗体的检测,其中8例阳性,阳性率为27%。42例ITP患者进行了甲、乙、丙、戊肝炎抗体的检测,其中15例阳性,包括:抗HBsAg(+)及抗HBc(+)4例,11例为抗HBsAg(+)、抗HBc(+)及抗HBe(+),阳性率为36%,另外,43例ITP患者进行了支原体抗体的检测,其中7例阳性,阳性率为16%。结论小儿特发性血小板减少性紫癜的发病可能与多种病毒感染有关。
Objective To investigate the relationship between idiopathic thrombocytopenic purpura and viral infection in children. Methods Parvovirus B19 detection: Polymerase chain reaction (PCR), kit purchased from China and the United States engineering company, the rest are using enzyme-linked immunosorbent assay. Results Twenty-four patients with ITP were tested for cytomegalovirus antibody, of which 5 were positive and the positive rate was 12%. 62 patients with ITP were tested for Epstein-Barr virus (EBV) antibody, of which 6 were positive, the positive rate was 10% and 70 Patients were tested for parvovirus B19, of which 30 were positive, the positive rate of about 43%. Thirty patients with ITP were tested for herpes simplex virus type I and type II antibodies, with a positive rate of 27%. Among them, 7 were positive for herpes simplex virus type 1 and 1 was herpes simplex virus type 2 antibody. Rubella virus antibodies were detected in 30 patients with ITP, of which 8 were positive and the positive rate was 27%. 42 cases of ITP patients were tested for A, B, C and E hepatitis antibodies, of which 15 were positive, including: 4 anti HBsAg (+) and anti HBc (+), 11 anti HBsAg (+) And anti-HBe (+), the positive rate was 36%. In addition, 43 cases of ITP patients were tested for mycoplasma antibodies, of which 7 were positive and the positive rate was 16%. Conclusion The incidence of idiopathic thrombocytopenic purpura in children may be related to a variety of viral infections.