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吡喹酮对血吸虫成虫有很强的杀伤力,但对虫卵的作用尚未取得一致的意见。脑型血吸虫病,主要与虫卵毒素的分泌及虫卵肉芽肿的形成有关。为此,作者研究了吡喹酮不同疗程对曼氏血吸虫虫卵的影响,并探讨了吡喹酮用于脑型血吸虫病的可行性。实验用小鼠,每鼠感染曼氏血吸虫波多黎各株尾蚴200条,7周后,选择每克粪便虫卵在100个以上的阳性鼠作为观察对象。将感染度相似的动物分配在同一实验组内。实验一:共4组,每组10个鼠。1.吡喹酮60mg/kg
Praziquantel has a strong lethal effect on adult schistosomiasis, but no consensus has been reached on its role. Cerebral schistosomiasis, mainly related to the secretion of egg-egg toxin and the formation of egg granuloma. To this end, the authors studied the praziquantel different courses of Schistosoma mansoni eggs, and discussed the praziquantel for the feasibility of cerebral schistosomiasis. Experimental mice were infected with 200 S. cercariae of Schistosoma mansoni per mouse. After seven weeks, 100 mice positive for fecal eggs per gram were selected as observation subjects. Animals with similar degrees of infection were assigned to the same experimental group. Experiment 1: A total of 4 groups of 10 mice each. Praziquantel 60mg / kg