滋养细胞中表皮生长因子受体表达丰富,该受体经表皮生长因子或转移生长因子-α激活后能够影响细胞的生长和代谢。体外研究发现多种淋巴细胞和巨噬细胞因子对人绒癌细胞的增殖有影响。为研究某些细胞因子通过改变表皮生长因子受体的表达而起作用的可能性,将JEG-3人绒癌细胞分别与不同浓度的白细胞介素1α(IL-1α)、白细胞介素1β(IL-1β)、白细胞介素2、γ-干扰素、粒细胞-巨噬细胞集落 Epidermal growth factor receptors are abundantly expressed in trophoblasts, which upon activation by epidermal growth factor or metastatic growth factor-alpha affect cell growth and metabolism. In vitro studies found that a variety of lymphocytes and macrophages affect the proliferation of human choriocarcinoma cells. To investigate the possibility that certain cytokines work by altering the expression of epidermal growth factor receptor, JEG-3 human choriocarcinoma cells were incubated with different concentrations of interleukin 1 alpha (IL-1 alpha), interleukin 1 beta IL-1β), interleukin 2, γ-interferon, granulocyte-macrophage colony