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目的调查分析抗结核药物诱导肝损害的临床特点。方法回顾性调查分析2008年2月至2012年3月在南充地区医院进行抗结核治疗患者的肝功能情况。结果符合本次调查标准的患者共2 136例,其中203例发生肝损害,发生率为9.50%;在203例肝损害患者中,180例(88.67%)发生于60d内;135例患者出现肝炎的典型表现(66.50%),68例患者则全无症状(33.50%),是在肝功能检查时发现异常。经治疗,189例(93.10%)患者痊愈或好转,14例(6.90%)患者未愈。结论抗结核药物导致的药物性肝损害应引起重视,对其应注意预防、早期诊断和及时合理的治疗。
Objective To investigate the clinical features of anti-TB drug-induced liver damage. Methods A retrospective investigation was conducted to analyze the liver function of patients undergoing anti-tuberculosis treatment in the Nanchong district hospital from February 2008 to March 2012. Results A total of 2 136 patients met the criteria of this survey, of which 203 patients developed liver damage with a rate of 9.50%. Among 203 patients with liver damage, 180 (88.67%) occurred within 60 days. 135 patients developed hepatitis (66.50%), and 68 patients were asymptomatic (33.50%), which were abnormal in liver function test. After treatment, 189 patients (93.10%) recovered or improved, and 14 patients (6.90%) did not heal. Conclusion Drug-induced liver damage caused by anti-TB drugs should pay attention to prevention, early diagnosis and timely and reasonable treatment.