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对于不同病因的43名高血压病患者,用心得安(121±12mg qd)和双氢克尿噻(50mg qd.)治疗75±9天,有15名患者血压没有恢复到正常范围,因而延长上述治疗方案并加 Oxdralazine(10～50mg qd)平均治疗68±35天后血压从180/110mm Hg降至145/90mm Hg,而没有直立性低血压重大副作用或肾小球过滤率的改变。这种联合用药是特别成功的,因为心得安能阻止由于 Oxdralazine 利尿而激活的肾素——血管紧
For 43 hypertensive patients with different etiologies, propranolol (121 ± 12 mg qd) and hydrochlorothiazide (50 mg qd.) Were administered for 75 ± 9 days, and 15 patients did not return to normal range with their blood pressure, thus prolonging The above treatment regimen with addition of Oxdralazine (10-50 mg qd) reduced blood pressure from 180/110 mm Hg to 145/90 mm Hg after an average of 68 ± 35 days of treatment without major adverse effects of orthostatic hypotension or changes in glomerular filtration rate. This combination is particularly successful because propranolol prevents renin-activated blood vessels that are activated by Oxdralazine diuretic