本文采用放射性核素示踪技术,进行了眩晕停贴膏透皮吸收的研究。体外法测定结果表明,几种动物皮肤的累积渗透量与时间成正比,提示眩晕停接近恒速渗透。从体内法测得的血药浓度时程曲线上可以看出,贴膏剂可维持较长时间的稳态血药浓度,因而可使药物作用时间延长、给药频率减少、不良反应降低。 In this paper, the use of radionuclide tracer technology, stunned paste posted transdermal absorption study. In vitro test results show that the accumulation of several animal skin penetration is proportional to time, suggesting that the dizziness stopped close to the constant rate of infiltration. As can be seen from the time course curve of plasma concentration measured by the in vivo method, the plaster can maintain the steady state plasma concentration for a long time, thus prolonging the acting time of the drug, reducing the frequency of administration and reducing the adverse reaction.