蟾毒灵是中药蟾酥中的一种活性单体,能抑制多种实体瘤及白血病肿瘤细胞增殖,诱导肿瘤细胞凋亡,逆转肿瘤细胞耐药,抑制肿瘤细胞迁移和浸润。该文就蟾毒灵对肝癌、肺癌、肠癌、胃癌、膀胱癌等多种肿瘤的体内外抑制作用及机制的最新研究成果进行了详尽综述,并综括了其新型制剂的研究进展,以期为其更深入的研究和应用提供参考。 Bufalin is a kind of active monomer in Chinese toad, which can inhibit the proliferation of various solid tumors and leukemia tumor cells, induce the apoptosis of tumor cells, reverse the drug resistance of tumor cells and inhibit the migration and infiltration of tumor cells. In this paper, the latest research results on the inhibitory effect and mechanism of bufalin on many kinds of tumors such as liver cancer, lung cancer, intestinal cancer, gastric cancer and bladder cancer were reviewed in detail, and the research progress of new preparations was summarized For its more in-depth research and application of reference.