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异基因造血干细胞移植供者Ｔ淋巴细胞与移植物抗宿主病（ＧＶＨＤ）的产生关系密切。以往唯一有效的方法是体外去除Ｔ淋巴细胞及应用免疫抑制剂。为了最大限度提高移植物抗白血病（ＧＶＬ）效应，防止肿瘤复发，同时减少ＧＶＨＤ发生，对Ｔ细胞进行基因改造是基因治疗肿瘤的方
Allogeneic hematopoietic stem cell transplantation donor T lymphocytes are closely related to the development of graft-versus-host disease (GVHD). The only effective method in the past was the removal of T lymphocytes in vitro and the use of immunosuppressants. In order to maximize the effect of graft-versus-leukemia (GVL), prevent tumor recurrence, and reduce the incidence of GVHD, genetic modification of T cells is a side of gene therapy for tumors.