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目的;研究碘缺乏与碘过多对大鼠甲状腺肿形成及其功能的影响。方法:实验分为三组,适碘组(对照组)、低碘组、高碘组,观察甲状腺及垂体重量,甲状腺组织及尿液的碘含量,血清及甲状腺组织激素水平。结果:低碘组甲状腺及垂体重量明显高于对照组,血清T_4及组织T_3、T_4、组织及尿碘含量均明显低于对照组,血清T_3在12周时代偿性增高,24周时明显下降。高碘组甲状腺及垂体重量,血清T_4及组织碘含量无明显改变,尿碘明显高于对照组,血清T_3及组织T_4于24周时明显低于对照组。结论:碘缺乏可引起大鼠甲肿和功能低下,而高碘尚未能引起甲肿,但抑制了甲状腺激素的合成和释放。
Objective To study the effects of iodine deficiency and iodine excess on goiter formation and function in rats. Methods: The experiment was divided into three groups, the iodine group (control group), low iodine group, high iodine group, thyroid and pituitary weight, thyroid tissue and urine iodine content, serum and thyroid hormone levels. Results: The thyroid weight and pituitary weight in the low iodine group were significantly higher than those in the control group. The contents of T_4, T_3, T_4, tissue and urinary iodine in serum were significantly lower than those in the control group. The serum T_3 increased compensatory at 12 weeks and significantly increased at 24 weeks decline. Thyroid and pituitary weight in iodine group, serum T 4 and tissue iodine content did not change significantly, urinary iodine was significantly higher than the control group, serum T 3 and tissue T 4 was significantly lower than the control group at 24 weeks. CONCLUSION: Iodine deficiency can cause hypothyroidism and hypofunction in rats. However, high iodine has not yet caused the formation of thyroid gland but inhibits thyroid hormone synthesis and release.