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溃疡病是一组致病机制尚未阐明的异源多因素疾病,目前尚缺乏研究溃疡病神经机制的实验模型。北京医科大学第三医院消化疾病研究中心邓小英等,采用能选择性破坏中脑黑质多巴胺能神经元的毒性物质1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP),以侧脑室、皮下、腹腔3种途径注射大鼠,建立了实验模型并对其机制进行了探讨。 结果从侧脑室、皮下、腹腔注射MPTP后均出现类似人的消化性溃疡,发病率分别为50％～100％、75％及100％,大鼠死亡率低,是研究神经递质与
Canker disease is a group of heterologous multifactorial diseases that have not been elucidated in pathogenesis. At present, there is no experimental model to study the neural mechanism of ulcer disease. Deng Xiaoying digestive disease research center of the Third Hospital of Beijing Medical University, etc., the use of selective destruction of midbrain nigral dopaminergic neurotoxic substances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The rats were injected intracerebroventricularly, subcutaneously and intraperitoneally. The experimental model was established and its mechanism was discussed. Results A similar human peptic ulcer developed after intracerebroventricular, subcutaneous and intraperitoneal injection of MPTP. The incidence rates were 50% -100%, 75% and 100%, respectively. The mortality rate in rats was low. It was a study of neurotransmitter and