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羟基黄烷醇{商品名肝得治[(+)-cyanidanol-3]}是一种黄酮类游离基团净化剂,可抑制肝细胞毒性化合物引起的脂质过氧化反应,从而保护实验动物的肝脏使之免受各种肝细胞毒性物质的损害。本文作者以双盲对照试验评价该药对急性病毒性肝炎的作用,同时还重点观察了对HBsAg清除的作用。材料和方法 5个医疗中心参加本项试验。有典型的肝炎症状、转氨酶达到正常最高值的4倍且无慢性肝病者确诊为急性肝炎。患者入院后每天用3 g(分3次服)肝得治或安慰剂,疗程8周。每周化验1次SGOT、SGPT、γ-GT(γ-谷氨酰转肽酶)、
Hydroxyl flavanols {brand name hepadrin [(+) - cyanidanol-3]} is a flavonoid free radical scavenger that inhibits lipid peroxidation caused by hepatotoxic compounds to protect experimental animals The liver is protected from various hepatotoxic substances. The authors evaluated the drug’s effect on acute viral hepatitis in a double-blind, controlled trial, and also focused on the role of HBsAg clearance. Materials and Methods Five medical centers participated in this trial. A typical hepatitis symptoms, aminotransferases up to 4 times the normal maximum and no diagnosis of acute hepatitis in patients with chronic liver disease. Patients admitted to the hospital daily with 3 g (3 times service) liver cure or placebo, treatment for 8 weeks. SGOT, SGPT, γ-GT (γ-glutamyl transpeptidase),