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以抗-Fas多克隆抗体，应用免疫组织化学技术，检测细胞凋亡因子Fas抗原在重症肝炎肝组织中的表达与分布。结果显示：63例各型重症肝炎肝组织Fas抗原总检出率90．46％（57／63），Fas抗原主要在肝细胞胞浆内表达。急性重症肝炎及亚急性重症肝炎Fas抗原分布于大片坏死区域中残留肝细胞内，周围淋巴细胞浸润；慢性重症肝炎Fas抗原分布于假小叶周边部肝细胞内，提示Fas抗原在重症肝炎时有介导细胞凋亡的作用。
Anti-Fas polyclonal antibody was used to detect the expression and distribution of Fas antigen in hepatic tissue of severe hepatitis by immunohistochemistry. The results showed that the total detection rate of Fas antigen in 63 cases of severe hepatitis was 90.46% (57/63). Fas antigen was mainly expressed in the cytoplasm of hepatocytes. Acute severe hepatitis and sub-acute severe hepatitis Fas antigen distribution in large areas of necrosis in the residual hepatocytes, peripheral lymphocyte infiltration; chronic severe hepatitis Fas antigen distribution in the peripheral lobe of hepatocytes, suggesting Fas antigen in severe hepatitis The role of cell apoptosis.