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本文报告了猪苓多糖注射液的临床与实验研究结果。用随机抽样分组和双盲配对法治疗慢性病毒性肝炎359例,疗效显著,其特点为能显著地改善患者症状,降低谷丙转氨酶,抑制病毒复制(尤其是 HBeAg 阴转),对肝组织损伤有修复作用,疗效较巩固,长期使用无毒副作用。药理实验表明,该药能减轻四氯化碳和 D-半乳糖胺引起的肝组织的病理损伤,促进肝损伤的恢复和肝脏的再生能力;促进豚鼠和熊猴乙型肝炎表面抗体的产生;使正常小鼠和肝损伤小鼠的腹腔巨噬细胞释放数和释放 H_2O_2能力明显增加。
This article reports the clinical and experimental results of Polyporus umbellatus polysaccharide injection. Using random sampling and double-blind pairing to treat 359 cases of chronic viral hepatitis, a significant effect, which is characterized by significant improvement in patients with symptoms, reduce alanine aminotransferase, inhibition of virus replication (especially HBeAg negative conversion), and liver damage The repair effect, the effect of consolidation, long-term use of non-toxic side effects. Pharmacological experiments show that the drug can reduce the pathological damage of liver tissue caused by carbon tetrachloride and D-galactosamine, promote the recovery of liver injury and liver regeneration, and promote the production of surface antibodies against hepatitis B in guinea pigs and bears. The number of peritoneal macrophages released from normal mice and liver injured mice and the ability to release H 2 O 2 increased significantly.