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解放军军事医学科学院放射与辐射医学研究所周钢桥研究员团队牵头联合国内多家科研机构,从遗传学、病毒学、功能和分子机制等多个角度,首次发现一种“整合因子复合体”基因INTS10可激活人体先天性免疫功能,发挥抑制乙肝病毒复制的作用。这一研究成果揭示了“整合因子复合体”具有此前从未被发现的抑制病原微生物感染的新作用,为其研究开辟了新的方向。同时,有助于深入了解乙肝病毒慢性感染的分子机制,为有效防治提供了理论依据和新的候选生物靶标。这一研究成果日前发表在《自然·通讯》杂志上。
Zhou Gangqiao, a researcher team led by the Institute of Radiation Medicine and Radiation Medicine of the PLA Academy of Military Medical Sciences, led a number of research institutes in the United Nations to find out for the first time that there is a “complex of integrative factors” gene from multiple perspectives of genetics, virology, function and molecular mechanism INTS10 can activate the body’s innate immune function, play a role in inhibiting hepatitis B virus replication. This research results reveal that the “integration factor complex” has a new role in inhibiting the infection of pathogenic microorganisms, which has never been discovered before, opening up a new direction for its research. At the same time, it helps to understand the molecular mechanism of chronic hepatitis B virus infection and provide a theoretical basis and a new candidate biological target for effective prevention and treatment. The research results recently published in “Nature Communications” magazine.