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反义核酸(Antisense RNA and DNA)对病毒引起疾病(包括AIDS)作用的研究发展迅速,并取得了较好结果,现已成为一门独特的新领域——抗病毒化学治疗(antiviralchemotherapy)。文献[1]报道了反义寡聚核苷酸,互补于反转录病毒RNA基因 5′端引物tRNA区序列的片段,和均聚体寡聚脱氧胞嘧啶核苷酸(homooligo dC_(14) )对小鼠腹水瘤病毒SRS(M-MuLV反转录病毒之一种)的抑制效果很好,病毒感染后宿主细胞(3T3)的生长抑制达到90％。本文报道进一步用均聚体寡聚脱氧胞嘧啶核苷酸研究对反转录病毒感染后的整体动物(小鼠)的治疗作用。实验结果表明所用核酸量到较适浓度时其抗病毒疗效达到80％,此时所
Antisense RNA (antisense RNA and DNA) has become a unique new field of research on the effects of viruses on diseases (including AIDS), and has achieved good results. Antiviral chemotherapy (antiviralchemotherapy). The literature [1] reported the antisense oligonucleotide, a fragment complementary to the tRNA region of the 5 ’end of the retroviral RNA gene and homooligo dC_ (14) ) Has a good inhibitory effect on mouse ascites virus SRS (one of the M-MuLV retroviruses), and the growth inhibition of host cells (3T3) after virus infection reaches 90%. This paper reports the further study of the therapeutic effect of monomeric oligodeoxycytidine nucleotides on whole animals (mice) following retroviral infection. The experimental results show that the amount of nucleic acid used to the appropriate concentration of its antiviral effect reached 80%, this time